Whichever layout you enjoy the most if you're just going to spam one, though that's pretty hard to do with nightmares since you have a 1/30 chance to get any specific dungeon. We don't know if the monster family buff made it to live release so anyone who says "farm X because Y monster gives more Z" is just speculating until we get official confirmation or someone does a serious loot study with significant numbers to prove the likelihood of it being in the game.

Diablo 4 Glyphs Tier List for Patch 1.1.1 

1. Mariners Refuge (S Tier)

No.Events: 2

Loot: 100%

Length: Short

Bosses: 1

Faction: Green Shadows

Tasks: Destroy Seabom 3

2. Sarat Lair (S Tier)

No.Events: 1 to 2

Loot: 95%

Length: Short

Bosses: 1

Faction: Spiders

Tasks: Destroy Spire 3

3. Hoarfrost Demise (S Tier)

No.Events: 1

Loot: 80%

Length: Very Shot

Bosses: 1

Faction: Marauders

Tasks: Destroy Skeletal 3

4. Shifting City (S Tier)

No.Events: 1

Loot: 100%

Length: Very Short

Bosses: 1

Faction: Skeletons, Marauders, Suiciders

Tasks: Return Pedestals 2/Collect Animus

5. Nostarava Deepwood (S Tier)

No.Events: 0

Loot: 70%

Length: Short

Bosses: 0

Faction: Trees, Skeletons

Tasks: Slay All/Slay Treebones 3

6. Komdor Temple (S Tier)

No.Events: 0

Loot: 90%

Length: Short

Bosses: 1

Faction: Marauders

Tasks: Slay Priests 3

7. Bastion of Faith (A Tier)

No.Events: 1 to 3

Loot: 130%

Length: Medium

Bosses: 0

Faction: Dredknlghts

Tasks: Collect Animus/Return Stones 1

Note: Too Many Elites

8. Uldur’s Cave (A Tier)

No.Events: 1 to 3

Loot: 130%

Length: Medium

Bosses: 0

Faction: Rhinos, Humans, Scorps, Hornet

Tasks: Destroy Barricades 3/Slay All

Note: Many Elites

9. Mercy’s Reach (A Tier)

No.Events: 1

Loot: 100%

Length: Long

Bosses: 1

Faction: Marauders, Qulrrats

Tasks: Slay Hunters 3/ Return Box 2

Notes: Many Elites

10. Twisted Hollow (A Tier)

No.Events: 1 to 2

Loot: 90%

Length: Medium

Bosses: 1

Faction: Rhinos,Trees, Green Shadows

Tasks: Collect Animus/Return Stones 1

11. Dead Man Dredge (A Tier)

No.Events: 2

Loot: 150%

Length: Medium

Bosses: 0

Faction: Mixed

Tasks: Collect Animus/Free Prisoners 7

12. Ancient Reservoir (A Tier)

No.Events: 0

Loot: 100%

Length: Medium

Bosses: 1

Faction: Skulls, Warden

Tasks: Slat All/Return Statue 2

13. Pallid Delve (A Tier)

No.Events: 1 to 2

Loot: 100%

Length: Medium

Bosses: 1

Faction: Humans/Spiders

Tasks: Slay All/Destroy Skeletal 3

14. Collapsed Vaults (A Tier)

No.Events: 1

Loot: 100%

Length: Medium

Bosses: 1

Faction: Skeletons

Tasks: Slay All / Return Statue 2

15. Heritcs Asylum (A Tier)

No.Events: 1

Loot: 70%

Length: Medium

Bosses: 3

Faction: Humans

Tasks: Collect Animus/Slay Scar

16. Dombainne Tunnels (A Tier)

No.Events: 0

Loot: 60%

Length: Medium

Bosses: 1

Faction: Moons

Tasks: Free Prisoners 3/Return Stone 1

17. Faceless Shrine (B Tier)

No.Events: 1

Loot: 80%

Length: Medium

Bosses: 1

Faction: Mixed

Tasks: Free Prisoners/Destroy Obelisk

18. Forgotten Ruins (B Tier)

No.Events: 0

Loot: 100%

Length: Long

Bosses: 1

Faction: Skeletons,Slither

Tasks: Slay All/Return Pedestal 2

Note: Many Doors

19. Immortal Imanation (B Tier)

No.Events: 1

Loot: 90%

Length: Medium

Bosses: 1

Faction: Green Shadows

Tasks: Destroy Blood 5

20. Betrayer’s Row (B Tier)

No.Events: 1

Loot: 100%

Length: Medium

Bosses: 1

Faction: Skeletons, Hornet, Warden, Marauders

Tasks: Return Bloodstone 2/Collect Animus

21. Garan Hold (B Tier)

No.Events: 1

Loot: 70%

Length: Medium

Bosses: 1

Faction: Suiciders, Skeletons

Tasks: Destroy Idols 3/Slay Keeper

Note: Many Doors

22. Iron Hold (B Tier)

No.Events: 2

Loot: 70%

Length: Long

Bosses: 1

Faction: Green Shadows, Wardens

Tasks: Slay Jailer 1/Return Stone 2

23. Tomb of the Saints (B Tier)

No.Events: 0

Loot: 80%

Length: Medium

Bosses: 1

Faction: Red Shadows, Scorps, Maggot

Tasks: Release Switch 2/Slay All

24. Path of the Blind (B Tier)

No.Events: 1

Loot: 40%

Length: Medium

Bosses: 1

Faction: Hornets, Rhinos, Humans

Tasks: Slay Guardians 2/Return Bloodstone 3

25. Akkhan’s Grasp (B Tier)

No.Events: 1

Loot: 110%

Length: Long

Bosses: 1

Faction: Warg, Bats, Bellyman, Humans

Tasks: Return Bloodstone 2/ Slay Vampire 2

26. Halls of the Damned (C Tier)

No.Events: 1

Loot: 90%

Length: Too Long

Bosses: 1

Faction: Red Shadows

Tasks: Destroy Idolf 2/Slay Guardian 1

Note: Too many Doors, 2 Teleport, Suiciders

27. Stockades (C Tier)

No.Events: 1

Loot: 85%

Length: Long

Bosses: 1

Faction: Skeletons, Suicider,Bellymob, Green Shadows

Tasks: Slay Warden/Collect Animus

28. Charnel House (D Tier)

No.Events: 0

Loot: 70%

Length: Long

Bosses: 1

Faction: Human/Maggot

Tasks: Free Prisoners/Destroy Pile 3

29. Lost Keep (D Tier)

No.Events: 1

Loot: 90%

Length: Long

Bosses: 1

Faction: Green Shadows/Humans

Tasks: Slay Fractured 3/Collect Animus

30. Kor Vallar (D Tier)

No.Events: 1

Loot: 30%

Length: Long

Bosses: 3

Faction: Humans

Tasks: Free Prisoners 5/Slay Lieutenant 1

Diablo 4 Leveling XP Tier List for Patch 1.1.1

1. Mariners Refuge (S Tier)

No.Events: 2

Loot: 100%

Length: Short

Bosses: 1

Faction: Green Shadows

Tasks: Destroy Seabom 3

2. Sarat Lair (S Tier)

No.Events: 1 to 2

Loot: 95%

Length: Short

Bosses: 1

Faction: Spiders

Tasks: Destroy Spire 3

3. Hoarfrost Demise (A Tier)

No.Events: 1

Loot: 80%

Length: Very Shot

Bosses: 1

Faction: Marauders

Tasks: Destroy Skeletal 3

4. Shifting City (B Tier)

No.Events: 1

Loot: 100%

Length: Very Short

Bosses: 1

Faction: Skeletons, Marauders, Suiciders

Tasks: Return Pedestals 2/Collect Animus

5. Nostarava Deepwood (B Tier)

No.Events: 0

Loot: 70%

Length: Short

Bosses: 0

Faction: Trees, Skeletons

Tasks: Slay All/Slay Treebones 3

6. Komdor Temple (B Tier)

No.Events: 0

Loot: 90%

Length: Short

Bosses: 1

Faction: Marauders

Tasks: Slay Priests 3

7. Bastion of Faith (S Tier)

No.Events: 1 to 3

Loot: 130%

Length: Medium

Bosses: 0

Faction: Dredknlghts

Tasks: Collect Animus/Return Stones 1

Note: Too Many Elites

8. Uldur’s Cave (S Tier)

No.Events: 1 to 3

Loot: 130%

Length: Medium

Bosses: 0

Faction: Rhinos, Humans, Scorps, Hornet

Tasks: Destroy Barricades 3/Slay All

Note: Many Elites

9. Mercy’s Reach (S Tier)

No.Events: 1

Loot: 100%

Length: Long

Bosses: 1

Faction: Marauders, Qulrrats

Tasks: Slay Hunters 3/ Return Box 2

Notes: Many Elites

10. Twisted Hollow (S Tier)

No.Events: 1 to 2

Loot: 90%

Length: Medium

Bosses: 1

Faction: Rhinos,Trees, Green Shadows

Tasks: Collect Animus/Return Stones 1

11. Dead Man Dredge (A Tier)

No.Events: 2

Loot: 150%

Length: Medium

Bosses: 0

Faction: Mixed

Tasks: Collect Animus/Free Prisoners 7

12. Ancient Reservoir (A Tier)

No.Events: 0

Loot: 100%

Length: Medium

Bosses: 1

Faction: Skulls, Warden

Tasks: Slat All/Return Statue 2

13. Pallid Delve (A Tier)

No.Events: 1 to 2

Loot: 100%

Length: Medium

Bosses: 1

Faction: Humans/Spiders

Tasks: Slay All/Destroy Skeletal 3

14. Collapsed Vaults (B Tier)

No.Events: 1

Loot: 100%

Length: Medium

Bosses: 1

Faction: Skeletons

Tasks: Slay All / Return Statue 2

15. Heritcs Asylum (B Tier)

No.Events: 1

Loot: 70%

Length: Medium

Bosses: 3

Faction: Humans

Tasks: Collect Animus/Slay Scar

16. Dombainne Tunnels (A Tier)

No.Events: 0

Loot: 60%

Length: Medium

Bosses: 1

Faction: Moons

Tasks: Free Prisoners 3/Return Stone 1

17. Faceless Shrine (A Tier)

No.Events: 1

Loot: 80%

Length: Medium

Bosses: 1

Faction: Mixed

Tasks: Free Prisoners/Destroy Obelisk

18. Forgotten Ruins (B Tier)

No.Events: 0

Loot: 100%

Length: Long

Bosses: 1

Faction: Skeletons,Slither

Tasks: Slay All/Return Pedestal 2

Note: Many Doors

19. Immortal Imanation (B Tier)

No.Events: 1

Loot: 90%

Length: Medium

Bosses: 1

Faction: Green Shadows

Tasks: Destroy Blood 5

20. Betrayer’s Row (B Tier)

No.Events: 1

Loot: 100%

Length: Medium

Bosses: 1

Faction: Skeletons, Hornet, Warden, Marauders

Tasks: Return Bloodstone 2/Collect Animus

21. Garan Hold (B Tier)

No.Events: 1

Loot: 70%

Length: Medium

Bosses: 1

Faction: Suiciders, Skeletons

Tasks: Destroy Idols 3/Slay Keeper

Note: Many Doors

22. Iron Hold (B Tier)

No.Events: 2

Loot: 70%

Length: Long

Bosses: 1

Faction: Green Shadows, Wardens

Tasks: Slay Jailer 1/Return Stone 2

23. Tomb of the Saints (B Tier)

No.Events: 0

Loot: 80%

Length: Medium

Bosses: 1

Faction: Red Shadows, Scorps, Maggot

Tasks: Release Switch 2/Slay All

24. Path of the Blind (B Tier)

No.Events: 1

Loot: 40%

Length: Medium

Bosses: 1

Faction: Hornets, Rhinos, Humans

Tasks: Slay Guardians 2/Return Bloodstone 3

25. Akkhan’s Grasp (C Tier)

No.Events: 1

Loot: 110%

Length: Long

Bosses: 1

Faction: Warg, Bats, Bellyman, Humans

Tasks: Return Bloodstone 2/ Slay Vampire 2

26. Halls of the Damned (C Tier)

No.Events: 1

Loot: 90%

Length: Too Long

Bosses: 1

Faction: Red Shadows

Tasks: Destroy Idolf 2/Slay Guardian 1

Note: Too many Doors, 2 Teleport, Suiciders

27. Stockades (C Tier)

No.Events: 1

Loot: 85%

Length: Long

Bosses: 1

Faction: Skeletons, Suicider,Bellymob, Green Shadows

Tasks: Slay Warden/Collect Animus

28. Charnel House (B Tier)

No.Events: 0

Loot: 70%

Length: Long

Bosses: 1

Faction: Human/Maggot

Tasks: Free Prisoners/Destroy Pile 3

29. Lost Keep (D Tier)

No.Events: 1

Loot: 90%

Length: Long

Bosses: 1

Faction: Green Shadows/Humans

Tasks: Slay Fractured 3/Collect Animus

30. Kor Vallar (D Tier)

No.Events: 1

Loot: 30%

Length: Long

Bosses: 3

Faction: Humans

Tasks: Free Prisoners 5/Slay Lieutenant 1