Whichever layout you enjoy the most if you're just going to spam one, though that's pretty hard to do with nightmares since you have a 1/30 chance to get any specific dungeon. We don't know if the monster family buff made it to live release so anyone who says "farm X because Y monster gives more Z" is just speculating until we get official confirmation or someone does a serious loot study with significant numbers to prove the likelihood of it being in the game.
Diablo 4 Glyphs Tier List for Patch 1.1.1
1. Mariners Refuge (S Tier)
No.Events: 2
Loot: 100%
Length: Short
Bosses: 1
Faction: Green Shadows
Tasks: Destroy Seabom 3
2. Sarat Lair (S Tier)
No.Events: 1 to 2
Loot: 95%
Length: Short
Bosses: 1
Faction: Spiders
Tasks: Destroy Spire 3
3. Hoarfrost Demise (S Tier)
No.Events: 1
Loot: 80%
Length: Very Shot
Bosses: 1
Faction: Marauders
Tasks: Destroy Skeletal 3
4. Shifting City (S Tier)
No.Events: 1
Loot: 100%
Length: Very Short
Bosses: 1
Faction: Skeletons, Marauders, Suiciders
Tasks: Return Pedestals 2/Collect Animus
5. Nostarava Deepwood (S Tier)
No.Events: 0
Loot: 70%
Length: Short
Bosses: 0
Faction: Trees, Skeletons
Tasks: Slay All/Slay Treebones 3
6. Komdor Temple (S Tier)
No.Events: 0
Loot: 90%
Length: Short
Bosses: 1
Faction: Marauders
Tasks: Slay Priests 3
7. Bastion of Faith (A Tier)
No.Events: 1 to 3
Loot: 130%
Length: Medium
Bosses: 0
Faction: Dredknlghts
Tasks: Collect Animus/Return Stones 1
Note: Too Many Elites
8. Uldur’s Cave (A Tier)
No.Events: 1 to 3
Loot: 130%
Length: Medium
Bosses: 0
Faction: Rhinos, Humans, Scorps, Hornet
Tasks: Destroy Barricades 3/Slay All
Note: Many Elites
9. Mercy’s Reach (A Tier)
No.Events: 1
Loot: 100%
Length: Long
Bosses: 1
Faction: Marauders, Qulrrats
Tasks: Slay Hunters 3/ Return Box 2
Notes: Many Elites
10. Twisted Hollow (A Tier)
No.Events: 1 to 2
Loot: 90%
Length: Medium
Bosses: 1
Faction: Rhinos,Trees, Green Shadows
Tasks: Collect Animus/Return Stones 1
11. Dead Man Dredge (A Tier)
No.Events: 2
Loot: 150%
Length: Medium
Bosses: 0
Faction: Mixed
Tasks: Collect Animus/Free Prisoners 7
12. Ancient Reservoir (A Tier)
No.Events: 0
Loot: 100%
Length: Medium
Bosses: 1
Faction: Skulls, Warden
Tasks: Slat All/Return Statue 2
13. Pallid Delve (A Tier)
No.Events: 1 to 2
Loot: 100%
Length: Medium
Bosses: 1
Faction: Humans/Spiders
Tasks: Slay All/Destroy Skeletal 3
14. Collapsed Vaults (A Tier)
No.Events: 1
Loot: 100%
Length: Medium
Bosses: 1
Faction: Skeletons
Tasks: Slay All / Return Statue 2
15. Heritcs Asylum (A Tier)
No.Events: 1
Loot: 70%
Length: Medium
Bosses: 3
Faction: Humans
Tasks: Collect Animus/Slay Scar
16. Dombainne Tunnels (A Tier)
No.Events: 0
Loot: 60%
Length: Medium
Bosses: 1
Faction: Moons
Tasks: Free Prisoners 3/Return Stone 1
17. Faceless Shrine (B Tier)
No.Events: 1
Loot: 80%
Length: Medium
Bosses: 1
Faction: Mixed
Tasks: Free Prisoners/Destroy Obelisk
18. Forgotten Ruins (B Tier)
No.Events: 0
Loot: 100%
Length: Long
Bosses: 1
Faction: Skeletons,Slither
Tasks: Slay All/Return Pedestal 2
Note: Many Doors
19. Immortal Imanation (B Tier)
No.Events: 1
Loot: 90%
Length: Medium
Bosses: 1
Faction: Green Shadows
Tasks: Destroy Blood 5
20. Betrayer’s Row (B Tier)
No.Events: 1
Loot: 100%
Length: Medium
Bosses: 1
Faction: Skeletons, Hornet, Warden, Marauders
Tasks: Return Bloodstone 2/Collect Animus
21. Garan Hold (B Tier)
No.Events: 1
Loot: 70%
Length: Medium
Bosses: 1
Faction: Suiciders, Skeletons
Tasks: Destroy Idols 3/Slay Keeper
Note: Many Doors
22. Iron Hold (B Tier)
No.Events: 2
Loot: 70%
Length: Long
Bosses: 1
Faction: Green Shadows, Wardens
Tasks: Slay Jailer 1/Return Stone 2
23. Tomb of the Saints (B Tier)
No.Events: 0
Loot: 80%
Length: Medium
Bosses: 1
Faction: Red Shadows, Scorps, Maggot
Tasks: Release Switch 2/Slay All
24. Path of the Blind (B Tier)
No.Events: 1
Loot: 40%
Length: Medium
Bosses: 1
Faction: Hornets, Rhinos, Humans
Tasks: Slay Guardians 2/Return Bloodstone 3
25. Akkhan’s Grasp (B Tier)
No.Events: 1
Loot: 110%
Length: Long
Bosses: 1
Faction: Warg, Bats, Bellyman, Humans
Tasks: Return Bloodstone 2/ Slay Vampire 2
26. Halls of the Damned (C Tier)
No.Events: 1
Loot: 90%
Length: Too Long
Bosses: 1
Faction: Red Shadows
Tasks: Destroy Idolf 2/Slay Guardian 1
Note: Too many Doors, 2 Teleport, Suiciders
27. Stockades (C Tier)
No.Events: 1
Loot: 85%
Length: Long
Bosses: 1
Faction: Skeletons, Suicider,Bellymob, Green Shadows
Tasks: Slay Warden/Collect Animus
28. Charnel House (D Tier)
No.Events: 0
Loot: 70%
Length: Long
Bosses: 1
Faction: Human/Maggot
Tasks: Free Prisoners/Destroy Pile 3
29. Lost Keep (D Tier)
No.Events: 1
Loot: 90%
Length: Long
Bosses: 1
Faction: Green Shadows/Humans
Tasks: Slay Fractured 3/Collect Animus
30. Kor Vallar (D Tier)
No.Events: 1
Loot: 30%
Length: Long
Bosses: 3
Faction: Humans
Tasks: Free Prisoners 5/Slay Lieutenant 1
Diablo 4 Leveling XP Tier List for Patch 1.1.1
1. Mariners Refuge (S Tier)
No.Events: 2
Loot: 100%
Length: Short
Bosses: 1
Faction: Green Shadows
Tasks: Destroy Seabom 3
2. Sarat Lair (S Tier)
No.Events: 1 to 2
Loot: 95%
Length: Short
Bosses: 1
Faction: Spiders
Tasks: Destroy Spire 3
3. Hoarfrost Demise (A Tier)
No.Events: 1
Loot: 80%
Length: Very Shot
Bosses: 1
Faction: Marauders
Tasks: Destroy Skeletal 3
4. Shifting City (B Tier)
No.Events: 1
Loot: 100%
Length: Very Short
Bosses: 1
Faction: Skeletons, Marauders, Suiciders
Tasks: Return Pedestals 2/Collect Animus
5. Nostarava Deepwood (B Tier)
No.Events: 0
Loot: 70%
Length: Short
Bosses: 0
Faction: Trees, Skeletons
Tasks: Slay All/Slay Treebones 3
6. Komdor Temple (B Tier)
No.Events: 0
Loot: 90%
Length: Short
Bosses: 1
Faction: Marauders
Tasks: Slay Priests 3
7. Bastion of Faith (S Tier)
No.Events: 1 to 3
Loot: 130%
Length: Medium
Bosses: 0
Faction: Dredknlghts
Tasks: Collect Animus/Return Stones 1
Note: Too Many Elites
8. Uldur’s Cave (S Tier)
No.Events: 1 to 3
Loot: 130%
Length: Medium
Bosses: 0
Faction: Rhinos, Humans, Scorps, Hornet
Tasks: Destroy Barricades 3/Slay All
Note: Many Elites
9. Mercy’s Reach (S Tier)
No.Events: 1
Loot: 100%
Length: Long
Bosses: 1
Faction: Marauders, Qulrrats
Tasks: Slay Hunters 3/ Return Box 2
Notes: Many Elites
10. Twisted Hollow (S Tier)
No.Events: 1 to 2
Loot: 90%
Length: Medium
Bosses: 1
Faction: Rhinos,Trees, Green Shadows
Tasks: Collect Animus/Return Stones 1
11. Dead Man Dredge (A Tier)
No.Events: 2
Loot: 150%
Length: Medium
Bosses: 0
Faction: Mixed
Tasks: Collect Animus/Free Prisoners 7
12. Ancient Reservoir (A Tier)
No.Events: 0
Loot: 100%
Length: Medium
Bosses: 1
Faction: Skulls, Warden
Tasks: Slat All/Return Statue 2
13. Pallid Delve (A Tier)
No.Events: 1 to 2
Loot: 100%
Length: Medium
Bosses: 1
Faction: Humans/Spiders
Tasks: Slay All/Destroy Skeletal 3
14. Collapsed Vaults (B Tier)
No.Events: 1
Loot: 100%
Length: Medium
Bosses: 1
Faction: Skeletons
Tasks: Slay All / Return Statue 2
15. Heritcs Asylum (B Tier)
No.Events: 1
Loot: 70%
Length: Medium
Bosses: 3
Faction: Humans
Tasks: Collect Animus/Slay Scar
16. Dombainne Tunnels (A Tier)
No.Events: 0
Loot: 60%
Length: Medium
Bosses: 1
Faction: Moons
Tasks: Free Prisoners 3/Return Stone 1
17. Faceless Shrine (A Tier)
No.Events: 1
Loot: 80%
Length: Medium
Bosses: 1
Faction: Mixed
Tasks: Free Prisoners/Destroy Obelisk
18. Forgotten Ruins (B Tier)
No.Events: 0
Loot: 100%
Length: Long
Bosses: 1
Faction: Skeletons,Slither
Tasks: Slay All/Return Pedestal 2
Note: Many Doors
19. Immortal Imanation (B Tier)
No.Events: 1
Loot: 90%
Length: Medium
Bosses: 1
Faction: Green Shadows
Tasks: Destroy Blood 5
20. Betrayer’s Row (B Tier)
No.Events: 1
Loot: 100%
Length: Medium
Bosses: 1
Faction: Skeletons, Hornet, Warden, Marauders
Tasks: Return Bloodstone 2/Collect Animus
21. Garan Hold (B Tier)
No.Events: 1
Loot: 70%
Length: Medium
Bosses: 1
Faction: Suiciders, Skeletons
Tasks: Destroy Idols 3/Slay Keeper
Note: Many Doors
22. Iron Hold (B Tier)
No.Events: 2
Loot: 70%
Length: Long
Bosses: 1
Faction: Green Shadows, Wardens
Tasks: Slay Jailer 1/Return Stone 2
23. Tomb of the Saints (B Tier)
No.Events: 0
Loot: 80%
Length: Medium
Bosses: 1
Faction: Red Shadows, Scorps, Maggot
Tasks: Release Switch 2/Slay All
24. Path of the Blind (B Tier)
No.Events: 1
Loot: 40%
Length: Medium
Bosses: 1
Faction: Hornets, Rhinos, Humans
Tasks: Slay Guardians 2/Return Bloodstone 3
25. Akkhan’s Grasp (C Tier)
No.Events: 1
Loot: 110%
Length: Long
Bosses: 1
Faction: Warg, Bats, Bellyman, Humans
Tasks: Return Bloodstone 2/ Slay Vampire 2
26. Halls of the Damned (C Tier)
No.Events: 1
Loot: 90%
Length: Too Long
Bosses: 1
Faction: Red Shadows
Tasks: Destroy Idolf 2/Slay Guardian 1
Note: Too many Doors, 2 Teleport, Suiciders
27. Stockades (C Tier)
No.Events: 1
Loot: 85%
Length: Long
Bosses: 1
Faction: Skeletons, Suicider,Bellymob, Green Shadows
Tasks: Slay Warden/Collect Animus
28. Charnel House (B Tier)
No.Events: 0
Loot: 70%
Length: Long
Bosses: 1
Faction: Human/Maggot
Tasks: Free Prisoners/Destroy Pile 3
29. Lost Keep (D Tier)
No.Events: 1
Loot: 90%
Length: Long
Bosses: 1
Faction: Green Shadows/Humans
Tasks: Slay Fractured 3/Collect Animus
30. Kor Vallar (D Tier)
No.Events: 1
Loot: 30%
Length: Long
Bosses: 3
Faction: Humans
Tasks: Free Prisoners 5/Slay Lieutenant 1
